Quote Originally Posted by Xelbair
Also i heard that small percentage of every drug you took is still inside your body.
That's not exactly true, however some drugs do have a really long half-life, and can stay in the body for a long time. In antidepressants, this "washout period" is particularly important.

About David's taking (St John's?) Wort at half the minimum prescribed dose, there's a thing called a Therapeutic Range, above which the drug is toxic, and below which the drug is ineffective. For example, if you had a minor headache, taking half a Panadol as opposed to the 1-2tabs won't actually have any effect.

But really, whatever works for you. If you feel relieved by taking such a low dose, go for it. Placebo effect can be quite a cost-effective treatment.

I'm actually gaining a lot of insight from this thread. I never realised people objected to antidepressants that much. I know the pros and cons from books and stuff, but hearing about it is another thing.