I can see Sakura in a teaching position in the academy, because she already fills an unofficial teacher role for the watchers of Naruto. Other than that, I've said this many times before, but I think Sakura will become the type of ninja who has a few very basic techniques, but uses them with such great efficiency that it puts everyone else to shame.
I think Hinata will end up with Naruto, though I wonder if this means Hinata is no longer in the Hyuuga clan, or if Naruto gets introduced into the Hyuuga clan.